AIDS TREATMENT NEWS No. 116 - December 7, 1990
John S. James
DNCB is in common use, however, as a diagnostic lab test applied topically to the skin, to assess delayed hypersensitivity in immune function; it has also been tried experimentally to treat alopecia, warts, and melanoma. Available as an industrial solvent, particularly in photographic development, DNCB has been reported to elicit an immunomodulatory activity from CD8 cells, and from Langerhans cells, which are considered a pivotal connection between the body's dermatological and immunological systems. When brushed onto a small area of the skin, DNCB gradually provokes a systemic immune reaction like that caused by poison oak or poison ivy, apparently inducing Langerhans cells to step up their capacity for signaling the proliferation of T-cells.
This study of DNCB is innovative for its plans to observe any correlation between skin and blood markers; it is designed only to monitor people who have already chosen to use DNCB (with or without AZT). It will be supervised by an HIV-knowledgeable physician on staff at Children's Hospital, Rafael Stricker, M. D. The protocol for the study was written by Dr. Stricker and Joseph Brewer of Project Inform. For information about participating, interested persons can call 415/552-7464.
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