AIDS TREATMENT NEWS No. 062 - August 12, 1988
John S. James
In the week before the article, two people who were consid- ering volunteering had asked us what we knew about the treatment.
CD4 is the protein found in the CD4 receptor site on T-helper and certain other cells. In the laboratory, manufactured CD4 provides an alternate target for HIV, preventing it from infecting new cells.
There will be a risk for the first person or first few per- sons who try this treatment, however. Some experts fear that injecting CD4 could cause the body to develop antibodies against its own T-helper cells, making AIDS symptoms worse. Animal and laboratory tests have been successful, but because this drug is so specific for the human immune system, these tests cannot rule out the possible danger.
Despite the risk, CD4 represents an important potential treatment for many people. It should be tested quickly. San Francisco General Hospital and other medical centers are now preparing to run initial trials.
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