(ATDN) Microsporidiosis


(ATDN) Microsporidiosis

Treatment Review #18; April 1995

Microsporidiosis is an intestinal infection that people with AIDS can get. The infection usually causes diarrhea. A trial is studying albendazole for the treatment of microsporidiosis. To participate in this study you must be HIV+, 18 years or older, and have biopsy-proven microsporidiosis within 90 days of study entry. You must have a history of an average of 3 liquid bowel movements per day for 4 weeks prior to study entry and, if taking antidiarrheal medication, be on a stable regimen for at least 7 days before study entry. You must be on a stable regimen of any other medication for 2 weeks before study entry. Pregnant women and nursing mothers are not allowed. You cannot have taken any potential antiprotozoal drugs such as mebendazole or metronidazole within 1 week of study entry or taken albendazole within 1 month of study entry.

Participants will be divided into two groups. One group will be treated with albendazole. The other group will be treated with placebo. Neither the doctor nor the participant will know which treatment is being given. After the 28 day double-blind period, all participants will receive open-label albendazole for 62 days. If you become hospitalized or have to remain in the hospital due to worsening diarrhea during the first 14 days of the study, you will be given open- label treatment. Treatment is for 3 months. Call The Network at (800) 734-7104 for more information.

Albendazole is also available through a compassionate use program for the treatment of microsporidiosis. Doctors should call (800) 355-8900 x 3909. They will be given a number to call at the FDA to obtain an IND number. Once that is complete, the pharmaceutical company will ship the drug directly to the physician.


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Always watch for outdated information. This article first appeard in 1995. This material is designed to support, not replace, the relationship that exists between you and your doctor.

Copyright © 1995 - AIDS Treatment Data Network. If you want to copy, reproduce or excerpt this information, please give us a call at (800) 734-7104. This helps up to keep track of where and how this information is being used. You can also Email us at network@atdn.org  http://206.179.124.69/network/index.html

This information is designed to support, not replace, the relationship that exists between you and your doctor.
©1995. AEGIS.