(ATDN) Aspirin Study Stopped

(ATDN) Aspirin Study Stopped

Treatment Review #17 - March 1995

The Community Research Initiative on AIDS (CRIA) has announced their study testing high-dose aspirin for the treatment of HIV infection has been stopped. Some side effects were seen in people in the study. The side effects were a reduction in the number of red blood cells and modest increases in liver enzymes. These side effects are common with the use of high-dose aspirin, and the study was designed so that safety checks would find out right away if the study should be stopped. Participants in the study who were having these side effects were taken off the study, and their lab values returned to normal.

The Data Safety Monitoring Board reviewed all data collected so far and recommended the trial be stopped. All participants have been discontinued from treatment. See the earlier article on Children and AZT for another example of how a Data Safety Monitoring Board (DSMB) works.

Strong cautions to people about trying aspirin on their own were part of all materials released in connection to this study. If you did try high dose aspirin on your own, you should see your doctor right away to make sure that your blood work is okay.

A related drug, salasalate, is being tested in a clinical trial as well. This drug does not have the same toxicity profile as aspirin - although it is still not yet known whether it is safe and effective for their treatment of HIV disease. CRIA also has other studies that are enrolling, such as U-90, also known as delavirdine. Results of this drug have so far been promising.

950301
ATR01705

Always watch for outdated information. This article first appeard in 1995. This material is designed to support, not replace, the relationship that exists between you and your doctor.

Copyright © 1995 - AIDS Treatment Data Network. If you want to copy, reproduce or excerpt this information, please give us a call at (800) 734-7104. This helps up to keep track of where and how this information is being used. You can also Email us at network@atdn.org http://206.179.124.69/network/index.html

This information is designed to support, not replace, the relationship that exists between you and your doctor.
©1995. AEGIS.