(ATDN) AZT and Children

(ATDN) AZT and Children

Treatment Review #17 - March 1995

One part of a trial that gave AZT to children has been stopped. The study compares three different treatments for children (ages 3 months to 18 years old) with symptomatic HIV infection. Interim results show that AZT by itself is the least effective of the three treatments, and the children taking AZT alone have higher rates of side effects. The children in the study are 3 months to 18 years old. The study is called ACTG 152. The groups in the study taking ddI alone, and ddI in combination with AZT will continue. Children who were taking AZT alone can switch over to one of these two groups if they want.

Studies are monitored by groups called independent data and safety monitoring boards (DSMB). If the board finds reason to stop a trial early, either because the drug is not working or because it is working so well that the drug should be made more widely available, changes are made in the study. The monitoring board found that the group of children taking AZT alone had more rapid rates of disease progression and more side effects.

The study opened in August 1991 and enrolled the last participant in August 1993, for a total of 839 participants. Further analysis of the study will take place in late 1995 after the study ends.

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Always watch for outdated information. This article first appeard in 1995. This material is designed to support, not replace, the relationship that exists between you and your doctor.

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This information is designed to support, not replace, the relationship that exists between you and your doctor.
©1995. AEGIS.