(ATDN) 3TC and AZT


(ATDN) 3TC and AZT

Treatment Review #17 - March 1995;

The combination of two drugs, AZT and 3TC, has shown surprisingly good results in several clinical trials that were recently reported on at a scientific conference held in Scotland. The two drug combination significantly reduced HIV levels in some of the people in the study. This combination was much more effective at reducing HIV levels in the blood than AZT or ddI taken by itself. The reduction of HIV levels has been sustained for almost a year in several of the study participants. In addition, people taking the combination had an overall increase in the number of T4 cells. Taking either AZT alone, or 3TC alone, does not produce these effects.

People taking the combination of 3TC and AZT did not experience any more side effects than if they were only taking AZT. Some people who take AZT experience side effects such as headaches, fatigue, and nausea. Some people taking 3TC experienced similar side effects, although more than 50% of the people in one study had no major side effects. The benefits of taking AZT in combination with 3TC were also seen in people who were already taking AZT alone. Another benefit that scientists around the world are eagerly waiting to confirm is 3TC's activity against the hepatitis B virus. In test tube studies, and in Phase I and Phase II studies, the drug was very effective against this virus.

The question that we still don't have the answer to is whether taking the combination of AZT and 3TC will help people who are HIV+ to live longer than if they don't take this drug combination. Like any other drugs approved for the treatment of AIDS and HIV-related conditions, most people with AIDS will not be able to get this drug unless it is approved by the federal government. Glaxo Pharmaceuticals, the company that owns the drug 3TC, has generously made it available to thousands of people nationwide through a special program. A new clinical trial comparing 3TC, AZT, and a protease inhibitor against AZT and 3TC has begun as well. If you would like more information about how to get 3TC, or any other experimental or approved drug give us a call at our nationwide, toll-free treatment access program at (800) 734-7104.


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This information is designed to support, not replace, the relationship that exists between you and your doctor.
©1995. AEGIS.