(ATDN) Thalidomide

(ATDN) Thalidomide

Treatment Review #15; December 1994

Thalidomide, a drug that was once prescribed as a sleeping pill, was banned in the early 1960s after it was found to cause deformed limbs in the children of women who took it early in pregnancy. Researchers have found that it may be a useful drug in treating symptoms of HIV infection, including wasting. Thalidomide is believed to work by interfering with the production of tumor necrosis factor, or TNF. It may also have other effects.

TNF is a chemical produced by the immune system to fight tumors and infections. TNF levels are often high in people with AIDS. High TNF levels are associated with more rapid progression to AIDS and with the development of HIV related central nervous system disease. High levels of TNF are thought to contribute to HIV wasting syndrome.

Celgene Corp. has started Phase II testing of its Synovir brand of thalidomide to treat weight loss in AIDS patients. The drug is used by some people with AIDS in the US, Canada and Brazil. Good results have been reported by individuals participating in the trial organized by Rockefeller University in New York City, particularly in controlling wasting and increasing weight and muscle. For information about thalidomide trials, call The Network. It may also be possible to get the drug if your doctor agrees to ask the drug company for it.

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Always watch for outdated information. This article first appeard in 1994. This material is designed to support, not replace, the relationship that exists between you and your doctor.

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This information is designed to support, not replace, the relationship that exists between you and your doctor.
©1994. AEGIS.