Treatment Review No. 14; November 1994
Resistance to other azole drugs used for treatment have also been shown. The drugs are ketoconazole, clotrimazole, and itraconazole.
Although these findings require further study, they suggest that chronic fluconazole therapy in HIV+ patients may be limited by the development of resistance to the drugs. Chronic use of a drug means it is used for a long time to suppress and prevent the disease. People who have become resistant to fluconazole may have to be treated with amphotericin B.
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