AIDSWEEKLY Plus; Monday, February 9, 2009
Staff Medical Writers

NewsRx -- Researchers detail in 'Detecting HIV associated neurocognitive disorders in adolescents: what is the best screening tool,' new data in HIV/AIDS co-infection. Researchers in the United States conducted a study "To examine the ability of the HIV-Dementia Scale (HDS) and Mini Mental State Exam (MMSE) to detect encephalopathy in adolescents living with human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome (AIDS). The study was based on chart review (N=71) from 1999 to 2006, extracting data from psychological testing, disease classification, and demographic variables."

"HDS and MMSE scores were independent. Diagnosis of encephalopathy used American Academy of Neurology Criteria. Receiver Operating Characteristic Curves were plotted. Six patients had encephalopathy. The HDS identified five of these cases (83% sensitivity, 76% specificity). The MMSE identified three cases (50% sensitivity, 92% specificity)," wrote M.E. Lyon and colleagues, Children's National Medical Center (see also HIV/AIDS Co-Infection).

The researchers concluded: "Based on the study results, the HDS appears to be clinically useful."

Lyon and colleagues published the results of their research in the Journal of Adolescent Health (Detecting HIV associated neurocognitive disorders in adolescents: what is the best screening tool? J Adolesc Health. 2009 Feb;44(2):133-5.

For additional information, contact M.E. Lyon, Children's National Medical Center and Children's Research Institute, Division of Adolescent and Young Adult Medicine, Washington, DC 20010-2970 USA..

The publisher of the Journal of Adolescent Health can be contacted at: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA.

Keywords: United States, Washington, HIV/AIDS Co-Infection, AIDS, Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome, Central Nervous System Disease, Dementia, HIV, Human Immunodeficiency Virus Neurological Disorder, Immunology, Mental Health, Psychology, Sexually Transmitted Disease, Viral, Virology.

This article was prepared by AIDS Weekly editors from staff and other reports.

Ref: Lyon ME, et al., “Detecting HIV associated neurocognitive disorders in adolescents: what is the best screening tool?”, J Adolesc Health. 2009 Feb;44(2):133-5.

2009-02-09
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