AIDSWEEKLY Plus; Monday, January 26, 2009
Staff Medical Writers

NewsRx -- According to a study from Birmingham, the United Kingdom, "Apolipoprotein E ( APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes."

"We investigated the potential association between the APOE-e4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-e4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count ( OR 8.3; 95% CI 2.4 to 28.5)," wrote A.N. Jayasuriya and colleagues (see also HIV/AIDS Co-Infection).

The researchers concluded: "To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-e4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV."

Jayasuriya and colleagues published the results of their research in Sexually Transmitted Infections (Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV. Sex Transm Infect, 2008 Dec;84(7):516-7).

For additional information, contact A.N. Jayasuriya, Heartlands Hospital, Dept. of Genitourinary Medical, Hawthorn House, Birmingham B9 5SS, W Midlands, UK.

The publisher of the journal Sexually Transmitted Infections can be contacted at: B M J Publishing Group, British Med Association House, Tavistock Square, London WC1H 9JR, England.

Keywords: United Kingdom, Birmingham, HIV/AIDS Co-Infection, AIDS, Acquired Immunodeficiency Syndrome, Genital Herpes, HIV, HSV-2, Herpes Simplex Virus, Herpesvirus, Human Immunodeficiency Virus Viral Infection, Virology.

This article was prepared by AIDS Weekly editors from staff and other reports.

2009-01-26
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