AIDSWEEKLY Plus; Monday, June 11, 2007
Staff Medical Writers

HIV is extremely variable, so an effective vaccine may need to stimulate the body to produce cross-reactive antibodies that will neutralize multiple viral strains. These results demonstrate that induction of truly broad-spectrum neutralizing antibodies may be an achievable goal. This groundbreaking study titled: “Extensively Cross-Reactive Anti-HIV-1 Neutralizing Antibodies Induced by gp140 Immunization” appears this week in the Early Edition of Proceedings of the National Academy of Sciences http://www.pnas.org/papbyrecent.shtml.

To be effective, an HIV vaccine must induce the body to produce cross-reactive antibodies that can neutralize multiple strains. USU Professors CAPT Gerald Quinnan, Jr., M.D., USPHS, and Christopher Broder, Ph.D., and their colleagues at USU attempted to elicit these broad-range antibodies in an animal model by immunizing with a particular HIV-1 surface protein, designated R2 gp140, and an immune response-boosting component. The researchers tested antibodies generated by the immunizations to determine their effectiveness in neutralizing the infectivity of a variety of HIV-1 strains. Antibodies produced as a result of immunization neutralized all 48 strains of HIV-1 tested. The results are encouraging for vaccine development, because they showed that it is possible to elicit a broad-spectrum antibody response.

The Uniformed Services University of the Health Sciences (http://www.usuhs.edu) is located on the grounds of the National Naval Medical Center in Bethesda, Md. The University provides military and public health-relevant education, research, service and consultation to the nation and the world. USU is a typical academic health center with a unique focus on health promotion and disease prevention, and with the specialized mission of educating health care practitioners to deal with peace- and wartime casualties, natural disasters, emerging infectious diseases and other public health emergencies.

This research was supported by a grant from a number of collaborators including the National Institutes of Health/NIAID and The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (HJF; www.hjf.org) is a not-for-profit organization authorized by Congress to support military medical research and education at USU and throughout military medicine. HJF’s technology transfer staff and the USU-HJF Joint Office of Technology Transfer encourage scientists and private industry to collaborate on research and development projects, with the goal of making innovative medical technologies available for public use.

Keywords: HIV/AIDS, AIDS, Acquired Immunodeficiency Syndrome, Biotechnology, HIV, Human Immunodeficiency Virus, Vaccines, Virology, Uniformed Services University of the Health Sciences.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Peng Fei Zhang, Fatim Cham, Ming Dong, et al., Extensively cross-reactive anti-HIV-1 neutralizing antibodies induced by gp140 immunization, Proc Natl Acad Sci U S A. 2007 May 31.

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