AEGiS-AIDSWeekly: HIV/AIDS Co-Infection Genetics: New HIV/AIDS co-infection genetics research reported from Sungkyunkwan University, Department of Dermatology

Important note: Information in this article was accurate in November 2006. The state of the art may have changed since the publication date.

HIV/AIDS Co-Infection Genetics: New HIV/AIDS co-infection genetics research reported from Sungkyunkwan University, Department of Dermatology

AIDSWEEKLY Plus; Monday, November 27, 2006
Staff Medical Writers

NewsRx -- Research findings, "Characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients," are discussed in a new report. According to a study from Seoul, Korea, "Although cytomegalovirus (CMV) disease is a severe complication among immunocompromised patients, its cutaneous features have not been frequently reported. As herpes simple virus (HSV) infection commonly develops in CMV skin lesions, a study is needed on the pathogenetic role of CMV in cutaneous lesion formation. The purpose of this study is to characterize the clinical and histopathological features of cutaneous CMV infection and to determine whether CMV plays a true pathogenetic role in cutaneous lesions, or if it is just an innocent bystander during HSV infection among non-AIDS (acquired immune deficiency syndrome), immunocompromised patients. A total of nine human immunodeficiency virus-negative patients diagnosed with cutaneous CMV infection from July 1999 to February 2005 at Samsung Medical Center were analysed in terms of their clinical and histopathological characteristics."

"In addition, we examined for the co-presence of HSV by performing immunohistochemical analysis and polymerase chain reaction. All the patients were immunocompromised; five had haematological diseases and four were organ transplant recipients. The clinical and histopathological features were similar to those of previous studies of patients with AIDS. Multiple anogenital ulcerations were the most frequent cutaneous presentation (66.7%). Most cytopathic changes were found in the dermis, particularly within the vascular endothelial cells (77.8%) and macrophages (66.7%). However, the association of CMV with concurrent HSV infection was even lower than that seen in patients with AIDS. Only one patient revealed a co-existing cutaneous HSV infection. In non-AIDS individuals, the cutaneous lesions from CMV infection showed similar clinical and histopathological features to those of patients with AIDS," wrote Y.L. Choi and colleagues, Sungkyunkwan University, Department of Dermatology.

The researchers concluded: "However, skin lesions may not be highly associated with HSV, and CMV does seem to contribute to lesion development as a cutaneous manifestation among the CMV infected, non-AIDS, immunocompromised patients."

Choi and colleagues published the results of their research in British Journal of Dermatology (Characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients. Br J Dermatol. 2006 Nov;155(5):977-82).

For additional information, contact Y.L. Choi, Samsung Medical Center, Dept. of Dermatology, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Gangnam-Gu, Seoul, Korea.

The publisher of the British Journal of Dermatology can be contacted at: Blackwell Publishing Ltd., 9600 Garsington Rd., Oxford OX4 2DG, Oxon, England.

Keywords: Korea, Seoul, HIV/AIDS Co-Infection Genetics, AIDS, Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome, CMV, Cytomegalovirus, Dermatology, Genetics, HIV, Herpes Simplex Virus, Herpesvirus, Human Immunodeficiency Virus Viral Infection, Immunology, Sexually Transmitted Disease, Virology.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Choi YL, Kim JA, Jang KT, et al., “Characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients”, Br J Dermatol. 2006 Nov;155(5):977-82.

PubMED Related articles Search

2006-11-27
AW061112

Copyright © 2006 - Charles Henderson, Publisher. All rights Reserved. Permission to reproduce granted to AEGIS by Charles W. Henderson. Authorization to reproduce for personal use granted granted by C. W. Henderson, Publisher, provided that the fee of US$4.50 per copy, per page is paid directly to the Copyright Clearance Center, 27 Congress Street, Salem, Massachusetts 01970, USA. Published by Charles Henderson, Publisher. Editorial & Publishing Office: P.O. Box 5528, Atlanta, GA 30307-0528 / Telephone: (800) 633-4931; Subscription Office: P.O. Box 830409, Birmingham, AL 35283-0409 / FAX: (205) 995-1588 http://www.newsrx.net

AEGiS is made possible through unrestricted grants from Boehringer Ingelheim, Elton John AIDS Foundation, Bridgestone/Firestone Charitable Trust, the National Library of Medicine, and donations from users like you. Always watch for outdated information. This article first appeared in 2006. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright © 1980,2006. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content.