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HIV/AIDS Cancer: Data from Hospital General Universitario, Internal Medicine Department provide new insights into HIV/AIDS cancer

AIDSWEEKLY Plus; Monday, November 20, 2006
Staff Medical Writers


NewsRx -- Fresh data on hiv/aids cancer are presented in the report "Occult lymphadenopathic Kaposi's sarcoma associated with severe pulmonary hypertension: A clinical hint about the potential role of HHV-8 in HIV-related pulmonary hypertension. Severe pulmonary hypertension (PH) mimicking idiopathic PH is an increasingly recognized complication of human immunodeficiency virus (HIV) infection. PH shares several histopathologic features with Kaposi's sarcoma (KS), the most common malignancy in AIDS patients, and molecular evidence of the vasculotropic Kaposi's sarcoma-associated herpesvirus or human herpesvirus 8 (HHV-8) has been found in the lung tissue of patients with the disease," scientists in Alicante, Spain report.

"Although the prevalence of HHV-8 infection is increased among HIV-infected patients, no clinical association between KS and PH has ever been reported. Herein, we described a 30-year-old HIV-infected female co-infected with HHV-8 who developed severe PH coincident with occult KS. The clinical presentation of KS was unusual and remained masqueraded for years as an indolent cervical lymphadenopathy, without the typical cutaneous lesions. This is the first ever-reported case of PH associated with KS. Although the co-occurrence of both diseases in this patient could have been just a coincidence, the observation may also indicate that a relationship between HHV-8 infection and HIV-associated PH exists," wrote F. Gutiérrez and colleagues, Hospital General Universitario, Internal Medicine Department.

The researchers concluded: "Coinfection with HHV-8 and occult lymphadenopatic KS should be considered in HIV-infected patients developing PH."

Gutiérrez and colleagues published their study in the Journal of Clinical Virology (Occult lymphadenopathic Kaposi's sarcoma associated with severe pulmonary hypertension: A clinical hint about the potential role of HHV-8 in HIV-related pulmonary hypertension?. J Clin Virol. 2006 Oct;37(2):79-82).

For additional information, contact F. Gutiérrez, Hospital General Universitario de Elche, Hospital General Universitario de Elche, Internal Medicine Department, Alicante, Spain.

The publisher's contact information for the Journal of Clinical Virology is: Elsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlands.

Keywords: Spain, Alicante, HIV/AIDS Cancer, AIDS, Acquired Immunodeficiency Syndrome, Clinical Virology, HIV, Herpesvirus, Human Immunodeficiency Virus Cancer, Hypertension, Internal Medicine, Kaposi Sarcoma, Oncology, Viral, Virology.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Gutierrez F, Masia M, Padilla S, et al., “Occult lymphadenopathic Kaposi's sarcoma associated with severe pulmonary hypertension: A clinical hint about the potential role of HHV-8 in HIV-related pulmonary hypertension?”, J Clin Virol. 2006 Oct;37(2):79-82.

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