HIV/AIDS & Herpesvirus 8: Human herpesvirus 8 is present in normal prostates of HIV-infected men

AIDSWEEKLY Plus; Monday, October 23, 2006
Staff Medical Writers

According to a recent report from the United States, "Human herpesvirus 8 (HHV-8) DNA has been detected in semen and prostatic tissues in some, but not all reports.

"We have analyzed prostate tissues from HHV-8 seropositive men for the expression of viral proteins and determined if expression of these proteins are associated with increased inflammation."

"Paraffin sections of noncancerous prostates from HHV-8 seropositive (n=16) and seronegative (n=2) men who died with AIDS were screened for expression of three viral proteins by immunohistochemistry. Levels of inflammation were determined by expression of CD68 and CD20. Cellular proliferation was determined by expression of Ki67," scientists wrote.

"Among the 16 HHV-8 seropositive cases," reported J.D. Montgomery and colleagues at the University of Pittsburgh, "68.9% (11/16) (95% C.I. -0.41-0.89) were positive for HHV-8 protein expression, while the 2 seronegative patients showed no HHV-8 protein expression. There was increased inflammation among HHV-8 positive prostates."

The authors concluded, "These results demonstrate that HHV-8 is present in normal prostates of HIV-infected men and the expression of viral proteins is associated with increased localized inflammation."

Montgomery and colleagues published their study in Prostate (Detection of human Herpesvirus 8 (HHV-8) in normal prostates. Prostate. 2006 Sep 1;66(12):1302-10).

For additional information, contact F.J. Jenkins, University of Pittsburgh, Dept. of Pathology, G16 Hillman Cancer Research Pavil, 5117 Center Avenue, Pittsburgh, PA 15213, USA.

The publisher's contact information for the journal Prostate is: Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA.

Keywords: Pittsburgh, Pennsylvania, United States, HIV/AIDS, Inflammation, Human Herpesvirus 8, Normal Prostate, Protein Expression.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Montgomery JD, Jacobson LP, Dhir R, et al., “Detection of human herpesvirus 8 (HHV-8) in normal prostates”, Prostate. 2006 Sep 1;66(12):1302-10.

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