HIV/AIDS Pathogenesis: HIV-1 integration in untreated infection occurs preferentially within genes

AIDSWEEKLY Plus; Monday, October 2, 2006
Staff Medical Writers

According to a study from the United States, "Previous analyses of human immunodeficiency virus type 1 (HIV-1) integration sites generated in infections in vitro or in patients in whom viral replication was repressed by antiviral therapy have demonstrated a preference for integration within protein-coding genes.

"We analyzed integration sites in peripheral blood mononuclear cells (PBMCs), spleen, lymph node, and cerebral cortex from patients with untreated HIV-1 infections."

"The great majority of integration sites in each tissue were within genes. Statistical analyses of the frequencies of integration in genes in PBMCs and lymph tissue demonstrated a strong preference for integration within genes.

"Although the sample size for brain tissue was too small to demonstrate a clear statistical preference for integration in genes, four of the five integration sites identified in brain were within genes," reported H.B. Liu and colleagues at Baylor University in Houston.

"Taken together," concluded scientists, "our data indicate that HIV-1 preferentially integrates within genes during untreated infection."

Liu and colleagues published their study in the Journal of Virology (Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genes. J Virol. 2006 Aug;80(15):7765-8).

For more information, contact A.P. Rice, Baylor College of Medicine, Dept. of Molecular Virology & Microbiology, 1 Baylor Plaza, Houston, TX 77030, USA.

Publisher contact information for the Journal of Virology is: American Society Microbiology, 1752 N St. NW, Washington, DC 20036-2904, USA.

Keywords: Houston, Texas, United States, HIV/AIDS, Viral Integration, Gene Integration, Untreated Infection, Brain.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Liu H, Dow EC, Arora R, et al., “Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genes”, J Virol. 2006 Aug;80(15):7765-8.

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