HIV/AIDS Drug Development: Antifungal protein isolated from the pea inhibits HIV-1 reverse transcriptase

AIDSWEEKLY Plus; Monday, September 11, 2006
Staff Medical Writers

"An antifungal protein with a molecular mass of 11 kDa and a lysine-rich N-terminal sequence was isolated from the seeds of the pea Pisum sativum var. arvense Poir," scientists writing in the journal Peptides report.

According to H.X. Wang and colleagues at the Chinese University of Hong Kong, "The antifungal protein was unadsorbed on DEAE-cellulose but adsorbed on Affi-gel blue gel and CM-cellulose.

"It exerted antifungal activity against Physalospora piricola with an IC₅₀ of 0.62 mcM, and also antifungal activity against Fusarium oxysporum and Mycosphaerella arachidicola."

"It inhibited human immunodeficiency virus type 1 reverse transcriptase with an IC₅₀ of 4.7 mcM," investigators concluded.

Wang and colleagues published their study in Peptides (An antifungal protein from the pea Pisum sativum var. arvense Poir. Peptides. 2006 Jul;27(7):1732-7).

Additional information can be obtained by contacting T.B. Ng, Chinese University of Hong Kong, Faculty Medical, Dept. of Biochemistry, Shatin, Hong Kong, People's Republic of China.

The publisher of the journal Peptides can be contacted at: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA.

Keywords: Hong Kong, People's Republic of China, HIV/AIDS, Pea Protein, Antifungal Protein, Pharmaceutical & Drug Development, HIV-1 RT Inhibition.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Wang HX, Ng TB., “An antifungal protein from the pea Pisum sativum var. arvense Poir”, Peptides. 2006 Jul;27(7):1732-7.

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