HIV/AIDS Diet & Nutrition: HIV-infected patients deficient in vitamin D

AIDSWEEKLY Plus; Monday, September 11, 2006
Staff Medical Writers

In a recent report, researchers in the United States conducted a study to "evaluate bone mineral metabolism in HIV infected and asymptomatic patients receiving highly active antiretroviral therapy (HAART) containing protease inhibitors (PI) and naive patients.

"We studied 30 asymptomatic HIV infected male patients, 13 in the naive group and 17 in the IP group, both without differences in demographics characteristics. We excluded women and patients with any known factor associated to osteopenia."

"We did a nutritional questionnaire, a DEXA scan in lumbar spine and femur, a study of CD4 lymphocytes, viral load and an analysis of bone formation and resorption markers in all patients.

"We compared vitamin D and PTH levels with a control group of healthy male volunteers age-pareated. For the statistical analysis we used the SPSS program," said A.M. Garcia Aparicio and colleagues at Hospital Virgen de la Salud in Toledo.

According to the authors, "Osteopenia was present in 17/30 (57%), 8/13 (61.5%) in the naive group and 9/17 (53%) in the PI group (not significant differences).

"We found a vitamin D deficiency in 86% of patients, with mean serum levels that was found to be significantly lower than those from a healthy control group (p=0.04). Testosterone level was significantly related to bone mineral density in lumbar spine (p>0.05)."

"HIV may be an individual risk factor in bone disorders, requiring calcium and vitamin D supplementation," investigators concluded.

Garcia Aparicio and colleagues published their study in Clinical Rheumatology (Abnormalities in the bone mineral metabolism in HIV-infected patients. Clin Rheumatol. 2006 Jul;25(4):537-9).

For additional information, contact A.M. Garcia Aparicio, Hospital Virgen Salud, Rheumatol Unit, Avenida Barber, 30, Toledo, Spain.

Publisher contact information for the journal Clinical Rheumatology is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords: Toledo, Spain, HIV/AIDS, Vitamin D, Testosterone Levels, Bone Mineral Metabolism, Diet and Nutrition.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Garcia Aparicio AM, Munoz Fernandez S, Gonzalez J, et al., “Abnormalities in the bone mineral metabolism in HIV-infected patients”, Clin Rheumatol. 2006 Jul;25(4):537-9.

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