AIDSWEEKLY Plus; Monday, May 23, 2005
Staff Medical Writers

According to a recently published study from Sweden, "Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses were determined in cultures of peripheral blood mononuclear cells from HIV-2-exposed uninfected individuals, HIV-2-infected individuals and HIV-negative controls in Guinea-Bissau."

"Increased HIV-2-specific T lymphocyte proliferative responses were detected in both groups compared to HIV-negative controls (healthy HIV-uninfected individuals without known exposure to an HIV-infected person); five out of 29 of the HIV-2-exposed uninfected and half (16 of 32) of the HIV-2-infected individuals had stimulation indexes >2, compared to one out of 49 of the HIV-negative controls (p=0.003 and p<0.0001, respectively).

"The exposed uninfected individuals had reactivity to a HIV-2 V3-peptide corresponding to amino acids 311-326 of the envelope glycoprotein, while the HIV-2-infected people reacted mainly to HIV-2 whole viral lysate," S. Andersson and colleagues at Orebro University Hospital.

"Thus," continued the authors, "this study demonstrates a high degree of HIV-2-specific T helper cell activity, as measured by lymphocyte proliferation, in HIV-2-exposed uninfected individuals as well as in HIV-2-infected subjects."

"These immune responses could be important for resistance to the infection and for the control of established infection and, thus, play a role in the lower transmission and progression of HIV-2 compared to HIV-1," Andersson concluded.

Andersson and coauthors published their study in Clinical and Experimental Immunology (Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses in HIV-2-infected and in HIV-2-exposed but uninfected individuals in Guinea-Bissau. Clin Exp Immunol. 2005 Mar;139(3):483-9.

For additional information, contact S. Andersson, Orebro University of Hospital, Dept. of Clinical Microbiology, SE-70185 Orebro, Sweden.

The publisher's contact information for the journal Clinical and Experimental Immunology is: Blackwell Publishing Ltd., 9600 Garsington Rd., Oxford OX4 2DG, Oxon, England.

Keywords: Orebro, Sweden, Africa, Exposed Uninfected, HIV 2, Immunity, Lymphocyte Proliferation, AIDS, HIV, Virology, Sexually Transmitted Disease, Immunology.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Andersson S, Larsen O, Da Silva Z, et al., Human immunodeficiency virus (HIV)-2-specific T lymphocyte proliferative responses in HIV-2-infected and in HIV-2-exposed but uninfected individuals in Guinea-Bissau, Clin Exp Immunol. 2005 Mar;139(3):483-9.

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