AIDSWEEKLY Plus; Monday, April 25, 2005
Staff Medical Writers

According to a study from Spain, "Within human immunodeficiency virus type 1 (HIV-1)-infected patients, there are those who have been infected for more than 10 years with a CD4+ cell count of >500 cells mcL^-1 and who remain asymptomatic without antiretroviral therapy; these patients are designated long-term, nonprogressors (LTNPs).

"In a set of 16 LTNPs, viral dating, DNA viral load, quasispecies heterogeneity and antibody (Ab) titres against gp160 and beta(2) microglobulin (beta(2)m) were determined. Plasma viral RNA and CD4+ and CD8+ T-cell numbers were estimated in more than three samples per patient."

"Host genetic characteristics, such as Delta32-CCR5 genotype and human leukocyte antigen (HLA) genotype and supertypes, and clinical-epidemiological factors were evaluated.

"Dating of global populations and of DNA and RNA viral quasispecies identified two subsets of patients: one displaying only ancestral sequences and the other displaying predominantly modern sequences," wrote G. Bello and coworkers at the Institute Salud Carlos III in Madrid.

"The ancestral patients displayed a significant reduction in RNA and DNA viral loads, quasispecies heterogeneity, CD8+ cell number, anti-gp160 Ab titres and beta(2)m level," the authors reported, "and they were also associated with better use of safe-sex practices and higher presence of the HLA sB58 supertype than the modem subset."

"Viral dating has therefore permitted the segregation of LTNPs into two subsets that show very different virological, immunological, host and clinical-epidemiological characteristics," said investigators.

Bello concluded, "Moreover, whereas the modern subset displayed low levels of virus replication, the ancestral group displayed not only a very limited virus replication, often to undetectable levels, but also very slow or arrested viral evolution, maintaining the close relationship of the viral population to the transmitted virus."

Bello and colleagues published the results of their research in the Journal of General Virology (A subset of human immunodeficiency virus type 1 long-term nonprogressors is characterized by the unique presence of ancestral sequences in the viral population. J Gen Virol. 2005 Feb;86(Pt 2):355-64.

For additional information, contact G. Bello, Institute Salud Carlos III, Center Nacl Microbiology, Madrid 28220, Spain.

The publisher of the Journal of General Virology can be contacted at: Society General Microbiology, Marlborough House, Basingstoke Rd., Spencers Woods, Reading RG7 1AG, Berks, England.

Keywords: Madrid, Spain, HIV/AIDS, Long-Term Non-Progressor, Virus Replication, Viral Evolution.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Bello G, Casado C, Sandonis V, et al., A subset of human immunodeficiency virus type 1 long-term non-progressors is characterized by the unique presence of ancestral sequences in the viral population, J Gen Virol. 2005 Feb;86(Pt 2):355-64.

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