AIDSWEEKLY Plus; Monday, December 27, 2004
Staff Medical Writers

According to published research from Denmark, "IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls."

"IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss," reported B. Lindegaard and colleagues.

"These findings suggest that IL-18 is linked to HIV-associated lipodystrophy," the authors concluded.

Lindegaard and colleagues published their findings in AIDS (Adipose tissue expression of IL-18 and HIV associated lipodystrophy. AIDS. 2004 Sep 24;18(14):1956-8.

Additional information can be obtained by contacting B. Lindegaard, Rigshosp, Copenhagen Muscle Research Center, Copenhagen, Denmark.

The publisher of the journal AIDS can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA.

The information in this article comes under the major subject areas of HIV/AIDS, Lipodystrophy and Interleukin-18.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Lindegaard B, Hansen AB, Pilegaard H "Adipose tissue expression of IL-18 and HIV-associated lipodystrophy", AIDS. 2004 Sep 24;18(14):1956-8.

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