AIDSWEEKLY Plus; Monday, May 24, 2004
Staff Medical Writers

"The localization of HIV-1 proviruses in compositional DNA fractions from 27 AIDS patients during the chronic phase of the disease with depletion of CD4+ and different levels of viremia" wrote scientists in France, showed the following:

"(1) At low viremia, proviruses are predominantly localized in the GC-richest isochores, which are characterized by an open chromatin structure; this result mimics findings on HIV-1 integration in early infected cells in culture,

"(2) At higher viremia, an increased distribution of proviruses in GC-poor isochores (which match the GC poorness of HIV-1) was found; this suggests a selection of cells in which the 'isopycnic' localization leads to a higher expression of proviruses and, in turn, to higher viremia,

"(3) At the highest viremia, integrations in GC-rich isochores are often predominant again, but generally not at the same level as in (1); this may be the consequence of new integrations from the extremely abundant RNA copies," concluded investigators.

Tsyba and colleagues published their study in Cellular and Molecular Life Sciences (Distribution of HIV-1 in the genomes of AIDS patients. Cell Mol Life Sci. 2004 Mar;61(6):721-6.

For additional information, contact G. Bernardi, Institute Jacques Monod, Genetics Molecular Laboratory, 2 Pl Jussieu, Tour 43, F-75005 Paris, France.

Publisher contact information for the journal Cellular and Molecular Life Sciences is: Birkhauser Verlag Ag, Viadukstrasse 40-44, PO Box 133, CH-4010 Basel, Switzerland.

The information in this article comes under the major subject areas of AIDS and HIV, Genomics and Viremia.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Tsyba L, Rynditch AV, Boeri E, et al., "Distribution of HIV-1 in the genomes of AIDS patients", Cell Mol Life Sci. 2004 Mar;61(6):721-6

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