Important note: Information in this article was accurate in May 2004. The state of the art may have changed since the publication date.
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AIDSWEEKLY Plus; Monday, May 10, 2004
Staff Medical Writers
Scientists in Baltimore "hypothesized that acute infection with human immunodeficiency virus (HIV) would diminish immunoregulation of chronic hepatitis B (CHB), resulting in higher blood hepatitis B virus (HBV) DNA levels.
"To test this hypothesis," C.L. Thio and colleagues at Johns Hopkins University "evaluated sequential HBV DNA levels in stored serum samples obtained from nine men with CHB who acquired HIV infection.
"Three patterns of changes in HBV DNA levels were noted after HIV seroconversion," they reported. "One man experienced the expected increase in HBV DNA, three men had stable HBV DNA levels, and, unexpectedly, five men had a mean decrease of 6.29 log10 copies/mL in the HBV DNA level, with hepatitis B e antigen no longer detectable in four.
"Acute HIV infection is not consistently associated with an increased blood HBV DNA level," the researchers concluded. "Additional research is needed to understand the mechanism for the unexpected reductions in HBV DNA levels associated with acute HIV infection."
Thio and colleagues published their study in Clinical Infectious Diseases (Changes in hepatitis B virus DNA levels with acute HIV infection. Clin Infect Dis. 2004 Apr 1;38(7):1024-9.
For additional information, contact C.L. Thio, 1503 East Jefferson St., Baltimore, MD 21231 USA.
The publisher's contact information for the journal Clinical Infectious Diseases is: University of Chicago Press, 1427 E. 60th St., Chicago, IL 60637-2954 USA.
The information in this article comes under the major subject areas of AIDS & HIV, Hepatitis B Virus, Hepatology, Infectious Disease and Virology.
This article was prepared by AIDS Weekly editors from staff and other reports.
Reference
Thio CL, Netski DM, Myung J, et al., "Changes in hepatitis B virus DNA levels with acute HIV infection", Clin Infect Dis. 2004 Apr 1;38(7):1024-9
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