AIDSWEEKLY Plus; Monday, November 3, 2003
Staff Medical Writers

In a recent study from Italy, ATAs "were clinically assessed in 2,258 HIV-1-infected outpatients consecutively observed in six Italian clinical centers".

The results revealed that ATAs were "present in 29.5% of the men and 41.9% of the women," according to M. Galli and coauthors at the University of Milan.

"A logistic regression model including age, HIV disease Centers for Disease Control stage, CD4 cell counts, HIV RNA load, the duration of antiretroviral therapy, the number of drugs taken, and the use of d4T [stavudine] showed that men had a 0.47 adjusted risk of presenting with ATAs (95% CI: 0.38-0.58, p<0.0001)," published data indicated.

"The risks of having ATAs (except circumscribed lipomas) in any body region, presenting with fat accumulation, or being affected by combined forms of ATA were also lower in men, whereas the risk of developing pure lipoatrophy was similar in the two genders," the investigators noted.

They concluded that "women are at higher risk of developing antiretroviral treatment-related ATAs and show a particular and complex ATA pattern."

Galli and colleagues published their study in the Journal of Acquired Immune Deficiency Syndromes (Gender differences in antiretroviral drug-related adipose tissue alterations - Women are at higher risk than men and develop particular lipodystrophy patterns. J Acquir Immune Defic Syndr. 2003 Sep 1;34(1):58-61.

For additional information, contact M. Galli, University of Milan, Ospedale Luigi Sacco, Institute of Infectious and Tropical Diseases, Via G.B. Grassi 74, I-20157 Milan, Italy.

The publisher of the Journal of Acquired Immune Deficiency Syndromes can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621 USA.

The information in this article comes under the major subject areas of AIDS & HIV, Virology and Women's Health.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

Galli M, Veglia F, Angarano G, et al. "Gender differences in antiretroviral drug-related adipose tissue alterations. Women are at higher risk than men and develop particular lipodystrophy patterns", J Acquir Immune Defic Syndr. 2003 Sep 1;34(1):58-61

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