AIDSWEEKLY Plus; Monday, October 6, 2003
Staff Medical Writers

In a recent study from the United States, "ten HIV-infected nucleoside reverse transcriptase inhibitor-treated subjects with lipoatrophy or sustained hyperlactatemia were given antioxidants: vitamins C, E, and N-acetyl cysteine."

"After 24 weeks, anthropometrics did not change significantly, except for a modest decrease in the waist-to-hip ratio," reported G. McComsey and coauthors working at Rainbow Babies and Children's Hospital in Cleveland.

"Fasting low-density lipoprotein cholesterol trended toward lower values," the published data indicated. However, "fasting glucose significantly increased along with a significant increase in homeostatic model assessment values, reflecting an increase in insulin resistance."

"Controlled trials are required to evaluate directly the effects of these agents on lipid and glucose metabolism," the researchers concluded.

McComsey and colleagues published their study in the Journal of Acquired Immune Deficiency Syndromes (Effect of antioxidants on glucose metabolism and plasma lipids in HIV-infected subjects with lipoatrophy. J Acquir Immune Defic Syndr. 2003 Aug 15;33(5):605-7.

For more information, contact G. McComsey, Rainbow Babies and Children's Hospital, 11100 Euclid Avenue, Mail Stop 8A, Cleveland, OH 44106, USA.

Publisher contact information for the Journal of Acquired Immune Deficiency Syndromes is: Lippincott Williams & Wilkins, 530 Walnut St., Philadelphia, PA 19106-3621, USA.

The information in this article comes under the major subject areas of AIDS & HIV, Antioxidants and Lipodystrophy.

This article was prepared by AIDS Weekly editors from staff and other reports.

Reference

McComsey G, Southwell H, Gripshover B, et al., "Effect of antioxidants on glucose metabolism and plasma lipids in HIV-infected subjects with lipoatrophy", J Acquir Immune Defic Syndr. 2003 Aug 15;33(5):605-7.

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