Important note: Information in this article was accurate in August 2003. The state of the art may have changed since the publication date. |
AIDSWEEKLY Plus; Monday, August 18, 2003
Staff Medical Writer
In a recent study from Canada, "mitochondrial:nuclear DNA (mtDNA:nDNA) ratios in blood cells were investigated in relation to selected human immunodeficiency virus antiretroviral drug regimens."
The 214 participants "continually received a regimen consisting of either:
saquinavir (SAQ) + ritonavir (RTV) + either nevirapine (NVP) or lamivudine (3TC) (n = 32), or
SAQ+RTV (± either NVP or 3TC) + either stavudine (d4T) (n = 127), didanosine (ddI) (n = 19), d4T+ddI (n = 21), or zidovudine (ZDV) (n = 15), for greater than or equal to 4 months," according to H.C.F. Cote and coauthors at the University of British Columbia."
"NVP- or 3TC-only regimens were associated with median mtDNA:nDNA ratios that were significantly higher than those for ddI- and d4T+ddI-containing regimens (p<0.01), but that were not significantly higher than those for d4T- or ZDV-containing regimens," test results showed. "Patients received thymidine analogue- and/or ddI-containing regimens for a shorter time (median, 14 vs. 24 months; p<0.01)."
"Because of survivor-bias effect, these results may represent a conservative estimate of these nucleosides' effect on mtDNA," the researchers concluded.
Cote and colleagues published the results of their research in the Journal of Infectious Diseases (Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens. J Infect Dis. 2003 Jun 15;187(12):1972-6.
For additional information, contact J.S.G. Montaner, University of British Columbia, St. Paul's Hospital, B.C. Centre for Excellence in HIV/AIDS, Department of Medicine, 667-1081 Burrard St., Vancouver, BC V6Z 1Y6, Canada.
The publisher of the Journal of Infectious Diseases can be contacted at: University of Chicago Press, 1427 E. 60th St., Chicago, IL 60637-2954, USA.
The information in this article comes under the major subject areas of Adverse Drug Effects, AIDS and HIV, DNA Research and Hematology.
This article was prepared by AIDS Weekly editors from staff and other reports.
Reference
Cote HC, Yip B, Asselin JJ, et al., "Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens", J Infect Dis. 2003 Jun 15;187(12):1972-6.
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