Important note: Information in this article was accurate in July 2003. The state of the art June have changed since the publication date. |
AIDSWEEKLY Plus; Monday, July 21, 2003
Michael Greer, Senior Medical Writer
"A single inoculation of herpes simplex virus type-1 (HSV-1) amplicon vectors encoding human immunodeficiency virus type-1 gp120 (HSV:gp120) results in robust, specific immune responses to gp120," explained Xiuqing Wang and colleagues at the University of Rochester Medical Center in Rochester, New York and the University of California at Davis.
Priming with amplicon plasmid DNA significantly augmented the cellular immune activity elicited by HSV:gp120 vaccination, Wang and coauthors found.
The researchers compared the effects of naked amplicon plasmid DNA priming followed by amplicon particle boosting and sequential administration of HSV:gp120. The prime-boost regimen induced the most powerful responses by acute and memory T cells, while two vaccinations with HSV:gp120 produced up to a 10-fold increase in overall anti-gp120 cellular immune activity, according to the report.
A single intramuscular immunization with HSV:gp120 produced a cellular immune response that peaked between nine and 28 days after treatment, study data showed. After this time, stable memory T-cell activity was observed.
T-cell responses were measured by tetramer staining (Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 2003 Jun 2;21(19-20):2288-97).
"Collectively, these results demonstrate the utility of HSV amplicon vectors in prime-boost regimens for HIV vaccine development," Wang and colleagues concluded.
The corresponding author for this report is Stephen Dewhurst, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA. E-mail: stephen_dewhurst@urmc.rochester.edu.
Key points reported in this study include:
This article was prepared by AIDS Weekly editors from staff and other reports.
Reference
Wang X, Wiley RD, Evans TG, et al., "Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming", Vaccine. 2003 Jun 2;21(19-20):2288-97.
PubMED Related articles Search
030721
AW030707
Copyright © 2003 - Charles Henderson, Publisher. All rights Reserved. Permission to reproduce granted to AEGIS by Charles W. Henderson. Authorization to reproduce for personal use granted granted by C. W. Henderson, Publisher, provided that the fee of US$4.50 per copy, per page is paid directly to the Copyright Clearance Center, 27 Congress Street, Salem, Massachusetts 01970, USA. Published by Charles Henderson, Publisher. Editorial & Publishing Office: P.O. Box 5528, Atlanta, GA 30307-0528 / Telephone: (800) 633-4931; Subscription Office: P.O. Box 830409, Birmingham, AL 35283-0409 / FAX: (205) 995-1588 http://www.newsrx.net
AEGiS is made possible through unrestricted grants from Boehringer Ingelheim, iMetrikus, Inc., the National Library of Medicine, and donations from users like you. Always watch for outdated information. This article first appeared in 2003. This material is designed to support, not replace, the relationship that exists between you and your doctor.
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Copyright © 1980,2003. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content.