Important note: Information in this article was accurate in October 2002. The state of the art may have changed since the publication date.AIDSWEEKLY Plus; October 21, 2002
Michael Greer, Senior Medical Writer
Joshua Rice and colleagues at Cornell University's Weill Medical College and the Rockefeller University's Aaron Diamond AIDS Research Center in New York City evaluated the antiviral efficacy of first generation Ad vectors.
The results of this preliminary study were promising, and warrant further investigation of this treatment strategy, Rice and coauthors said.
The researchers infected healthy alveolar macrophages with Ad vectors carrying therapeutic genes in the deleted E1 region. Treated cells were later infected with a dual-tropic HIV strain.
The protective genes transferred by the Ad vectors significantly impaired subsequent HIV replication, with higher Ad doses providing greater degrees of viral suppression, according to the report. Similar results were seen when macrophages were treated with transferred CCR5 and CXCR4 coreceptors to ensure HIV access.
The choice of Ad vector expression cassette or backbone E4 genes had no discernable effect on gene transfer efficacy (Inhibition of HIV-1 replication in alveolar macrophages by adenovirus gene transfer vectors. Am J Respir Cell Mol Biol 2002 Aug;27(2):214-9.
"These observations have implications regarding pulmonary host responses associated with HIV-1 infection, as well as possibly uncovering new therapeutic strategies against HIV-1 infection," Rice and colleagues concluded.
The corresponding author for this report is Ronald G. Crystal, Institute of Genetic Medicine, Weill Medical College of Cornell University, 515 East 71st Street, Suite 1000, New York, NY 10021, USA. E-mail: geneticmedicine@med.cornell.edu.
A search at www.NewsRx.net using the search term "AIDS and HIV therapy" yielded 1193 articles in 29 specialized reports.
Key points reported in this study include:
This article was prepared by AIDS Weekly editors from staff and other reports.
Reference
Rice J, Connor R, Worgall S, et. al., "Inhibition of HIV-1 replication in alveolar macrophages by adenovirus gene transfer vectors.", Am J Respir Cell Mol Biol 2002 Aug;27(2):214-9.
021021
AW021010
Copyright © 2002 - Charles Henderson, Publisher. All rights Reserved. Permission to reproduce granted to AEGIS by Charles W. Henderson. Authorization to reproduce for personal use granted granted by C. W. Henderson, Publisher, provided that the fee of US$4.50 per copy, per page is paid directly to the Copyright Clearance Center, 27 Congress Street, Salem, Massachusetts 01970, USA. Published by Charles Henderson, Publisher. Editorial & Publishing Office: P.O. Box 5528, Atlanta, GA 30307-0528 / Telephone: (800) 633-4931; Subscription Office: P.O. Box 830409, Birmingham, AL 35283-0409 / FAX: (205) 995-1588 http://www.newsrx.net
AEGiS is made possible through unrestricted grants from Boehringer Ingelheim, iMetrikus, Inc., the National Library of Medicine, and donations from users like you. Always watch for outdated information. This article first appeared in 2002. This material is designed to support, not replace, the relationship that exists between you and your doctor.
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Copyright © 1980,2002. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content.