Important note: Information in this article was accurate in September 2001. The state of the art may have changed since the publication date.AIDSWEEKLY Plus; Monday, September 3, 2001
Michael Greer, Staff Medical Writer
NewsRx - Levels of soluble CD23 in the cerebrospinal fluid (CSF) of AIDS patients can be used to diagnose AIDS-related non-Hodgkin lymphoma that has spread to the brain and/or nervous system, researchers in Europe report.
"AIDS-related non-Hodgkin's lymphoma (NHL) includes systemic lymphomas, often with brain involvement, and primary central nervous system (CNS) lymphomas," according to Francesca Chiodi and colleagues at Sweden's Karolinska Institute and Astrid Lindgren Children's Hospital and Italy's San Raffaele Hospital.
Measurements of CSF soluble CD23 concentrations can be useful for differentiating NHL with brain involvement from other forms of the malignancy or other disorders, Chiodi and coworkers said.
Patients suffering from AIDS-related NHL with brain involvement displayed significantly higher levels of soluble CD23 in their cerebrospinal fluid than patients with systemic NHL that had not spread to the brain or CNS, study data showed. Soluble CD23 levels in CNS lymphoma patients were also significantly higher than in AIDS patients with other neurological disorders, including AIDS dementia, cerebral toxoplasmosis, and progressive multifocal leukoencephalitis.
Many, but not all, patients suffering AIDS-related lymphoma were also infected with Epstein-Barr virus. Levels of soluble CD23 in cerebrospinal fluid were not affected by coinfection with Epstein-Barr, the researchers noted.
The specificity of soluble CD23 levels as a test for lymphoma with CNS involvement was 94%, with a sensitivity of 77% ("Soluble CD23 in cerebrospinal fluid: A marker of AIDS-related non-Hodgkin's lymphoma in the brain," AIDS 2001 Jun 15;15(9):1109-1113.
"The sCD23 in CSF of HIV-1 infected patients may represent an additional, non-invasive marker for diagnosis of brain involvement in AIDS-related NHL," Chiodi and coauthors concluded.
The corresponding author for this report is Francesca Chiodi, Karolinska Institute, Center for Microbiology and Tumor Biology, Nobelsvag 16, S-17177 Stockholm, Sweden.
Key points reported in this study include:
This article was prepared by AIDS Weekly editors from staff and other reports.
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