AIDSWEEKLY Plus; Monday, September 21, 1998
Daniel J. DeNoon, Senior Editor
Hugo Soudeyns of Beaumont Hospital, Lausanne, Switzerland, and colleagues analyzed cytotoxic T-lymphocyte (CTL) subsets in 24 patients with primary HIV infection.
The 11 patients who received no treatment had a massive expansion of virtually all CTL subsets as defined by the T- cell receptor beta chains (V(beta)). But nine patients treated with highly active antiretroviral therapy (HAART) had rapid stabilization of V(beta) subsets.
"A global mobilization of the CD8 subtypes occurs in primary HIV infection, and HAART reduces the mobilization," Soudeyns said in a presentation to the 12th World AIDS Conference, held June 28-July 3, 1998, in Geneva, Switzerland.
Nearly all of the V(beta) expansion seen in the study was due to oligoclonal expansion of CD8(+) CTLs. Expansion increased over time in seven of the 11 untreated patients and decreased in all the patients who received HAART.
"Rapid stabilization may prevent exhaustion of CD8 CTL clones," Soudeyns said.
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