Important note: Information in this article was accurate in 2006. The state of the art may have changed since the publication date.
|
|
United Press International - November 16, 2006
Dr. Barney Graham and colleagues from the National Institutes of Health Vaccine Research Center, the Fred Hutchinson Cancer Research Center in Seattle, and GenVec Inc. tested two possible HIV vaccines with the hope of producing an immune response in healthy, uninfected adults.
One candidate was a plasmid DNA-based vaccine expressing genes from three dominant HIV subtypes, and the second used recombinant adenovirus serotype 5 (rAd5) as a vector to deliver similar HIV strains.
Both vaccines were tested in healthy, uninfected adult volunteers. The DNA vaccine was found safe and well-tolerated. By the 12th week following immunization, 97.5 percent of vaccinees experienced positive CD4 T cell responses and 40 percent experienced positive CD8 T cell responses.
The recombinant vector vaccine was also well-tolerated but higher doses led to adverse events such as pain and fever. By the fourth week following immunization, 93.3 percent of vaccinees experienced positive CD4 T cell responses, and 60 percent experienced positive CD8 T cell responses.
The study is detailed in the Dec. 15 issue of The Journal of Infectious Diseases.
061116
UP061120
Copyright © 2006 - United Press International. All rights reserved. Reproduced with permission. Reproduction of this article (other than one copy for personal reference) must be cleared through United Press International, Permissions Desk, 1510 H St. N.W. Washington DC 2005. Main Phone Switchboard: 202-898-8000 FAX: 202-898-8057 or 202-898-8147 Email: info@upi.com.
AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Elton John AIDS Foundation UK, the National Library of Medicine, AIDS Walk of Orange County, and donations from users like you.
Always watch for outdated information. This article first appeared in 2006. This material is designed to support, not replace, the relationship that exists between you and your doctor.
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Copyright ©1980, 2006. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .