Important note: Information in this article was accurate in 2004. The state of the art may have changed since the publication date.
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United Press International - Monday, August 16, 2004
The scientists at the National Cancer Institute of the National Institutes of Health also have linked HIV, which causes AIDS, with several genes not previously associated with it.
Current HIV/AIDS drugs, called antiretrovirals, target HIV replication but cannot fully eradicate the virus because HIV also rests latently in a non-replicating stage in some cells, researchers said.
NCI researchers studied gene expression in latently infected cells and found they have a different pattern of gene expression than uninfected cells.
They identified a gene target that could be used to activate HIV replication in latently infected cells so it can be treated or eradicated by drug therapy.
They also found a compound, called resveratrol, activates a gene that slows cell growth so HIV replicates.
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