AEGiS-UPI: HIV May Be Treated with Gene Therapy United Press InternationalImportant note: Information in this article was accurate in 2004. The state of the art may have changed since the publication date.
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HIV May Be Treated with Gene Therapy

United Press International - Tuesday, May 25, 2004


STANFORD, Calif. -- California researchers are seeking volunteers with HIV to test a method of empowering an infected person's own cells to destroy HIV as it enters the cell.

Researchers at Stanford University School of Medicine said the process used the patient's stem cells -- ones in the bloodstream that form the different immune system cell that HIV infects, such as T cells and macrophages -- and inserts a gene that produces an HIV-obliterating enzyme.

"This is a broad-spectrum treatment that could integrate well with other therapies as the disease progresses, as it will in all patients eventually," said Thomas Merigan, who is collaborating with other researchers at UCLA and St. Vincent's Hospital in Sydney, Australia. "The goal is to genetically engineer the cells and make them resistant to infection."

A total of 70 patients will be enrolled at three sites for this stage of the testing and given gene therapy or a dummy gene.
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