The San Francisco Chronicle - Wednesday, July 12, 2000
Sabin Russell
The International AIDS Vaccine Initiative, funded in part by Microsoft Chairman Bill Gates, touted the candidate vaccine as the first "designed-for-Africa" immunization to reach the testing phase. Initially, 18 volunteers, including a member of Britain's Parliament, will serve as the human trial subjects. Later the vaccine will be tested on volunteers in Nairobi.
Unlike vaccines designed to stir up antibodies that can fend off invading microbes, the so-called DNA vaccine is engineered to stimulate production of a kind of killer white blood cell found in great quantities in the blood of Nairobi prostitutes, who caught researchers' attention because they remain HIV-negative despite regular exposure to HIV- infected men. An Oxford University-University of Nairobi partnership developed the vaccine to target the specific strain of virus that has struck hard in Kenya, the so-called subtype A.
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