Important note: Information in this article was accurate in 2007. The state of the art may have changed since the publication date.

Reuters NewMedia - October 26, 2007

Use of face masks, reducing how long patients spend in the hospital and treating more people as outpatients could prevent nearly a third of new XDR TB infections, at least in one area of rural South Africa, the researchers reported in the Lancet medical journal.

"Supplementing this approach with improved ventilation, rapid drug-resistance testing, HIV treatment, and tuberculosis isolation facilities could avert 48 percent of XDR tuberculosis cases by the end of 2012," Dr. Sanjay Basu of Yale University in Connecticut and colleagues wrote.

XDR TB is the most dangerous form of the common infection. It resists many of the antibiotics used to treat the disease and is far more likely to kill patients.

XDR tuberculosis has been reported in 37 countries but South Africa has had the largest cluster of cases.

"The first 53 cases were reported from the rural town of Tugela Ferry, where infected patients had a median survival time of only 16 days from sputum collection, and had a 98 percent mortality rate," Basu's team wrote.

Ironically, more than half the cases appeared to have originated in the hospital, they said.

Basu and colleagues combined computer modeling with data from a multiyear study of TB incidence to investigate the effect of various control measures.

They found that if nothing was done, around 1,300 new cases of XDR tuberculosis could occur in the Tugela Ferry area by 2012, more than half which are likely to be transmitted within the hospital.

Use of masks alone would prevent just under 10 percent of new infections but might protect hospital staff.

They said their findings probably apply to similar rural African settings, where XDR TB is growing.

"Multidrug and extensive drug resistance are monsters of our own creation," Dr. Travis Porco of the University of California, San Francisco, and Dr. Wayne Getz of the University of California, Berkeley, wrote in a commentary in Lancet.

"They might be with us longer than we think and might need us to spend more than governments or institutions are willing or able to pay. Although scientific warnings are often ignored until too late, effective interventions for the control of XDR tuberculosis in Africa are national and international responsibilities, and the world community ignores this message at great peril," they wrote.

The World Health Organization estimates that a third of the world's population is infected with TB, most with a latent form of the bacterial infection that does not make them ill.

WHO estimates that up to 30,000 people have XDR TB.

071026
RE071027

Always watch for outdated information. This article first appeared in 2007. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 2007. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .