Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.
Important note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.
Reuters NewMedia, Inc. - Sunday September 14 12:00 AM EDT
The new soft-gel formulation, to be marketed as Fortovase, gave 10 times the exposure that current, hard-gel version of Invirase gives, Roche said in a statement.
When given in triple-combination therapy, the drug helped lower blood levels of the HIV virus to below detectable limits, scientists working with Roche told a meeting of the Infectious Disease Society of America.
They said they gave Fortovase along with the more standard drugs AZT and 3TC to 41 volunteers who had not had any drugs before. Adverse events such as nausea and diarrhea were mild and short-lived, they said.
Roche has asked for U.S. Food and Drug Administration approval to market the drug and expects it by the end of the year.
Doctors are seeking as many versions of HIV drugs as possible because the virus mutates into resistant strains quickly.
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