AEGiS-Reuters: (RE) Blood transfusions are safer than believed, says study

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(RE) Blood transfusions are safer than believed, says study

Reuters NewMedia, Inc. - 27 Dec 1995


BOSTON (Reuter) - The risk of getting AIDS through a transfusion of blood or blood products may be only half as great as originally believed, according to an assessment to be published in Thursday's New England Journal of Medicine.

A team led by Dr Eve Lackritz of the Centers for Disease Control and Prevention (CDC) in Atlanta concluded that among 12 million donations collected nationally each year only an estimated 18 to 27 were infectious. The actual risk was higher because blood donations are divided into several elements and a person who received one transfusion usually required others.

For the typical recipient who gets blood products from five or six donors, the risk of getting HIV could be as high as 1 in 83,000 or as low as 1 in 122,000. The actual risk is probably far lower in individual cases because 25 to 50 percent of blood transfusion recipients die from their underlying medical condition long before AIDS has time to develop, the Lackritz team said.

Earlier estimates were higher because older tests designed to look for HIV had a 45-day ``window'' in which a person's blood could be newly infectious and the test could not sense it. The window in the current tests is about 25 days.

There have been suggestions that an additional test should be used to find some of the remaining infected blood samples that now go undetected. But Lackritz and her colleagues say the added test, which looks for a protein known as the p24 antigen, would detect only an additional four to six infected points of blood among the 12 million pints donated nationwide, and they say the small benefit may not be worth the cost.

The conclusions were drawn from tests on more than four million blood donations in 1992 and 1993 from 19 regions served by the American Red Cross, plus results from another five million samples in 23 other regions.


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