AEGiS-PRn: Interferon Sciences Commences Phase 2 Clinical Trial in Patients Co-Infected With HIV and Hepatitis C PRNewswireImportant note: Information in this article was accurate in 1997. The state of the art may have changed since the publication date.
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Interferon Sciences Commences Phase 2 Clinical Trial in Patients Co-Infected With HIV and Hepatitis C

PR Newswire; Friday December 19, 11:56 am EST


NEW BRUNSWICK, N.J., Dec. 19 /PRNewswire/ -- Interferon Sciences, Inc. (ISI) (Nasdaq-NNM: IFSC - news) announced today that patient enrollment has commenced in a multi-center, open label, Phase 2 clinical trial designed to evaluate the safety and efficacy of ALFERON N Injection in patients co-infected with HIV and hepatitis C virus (HCV). This trial consists of a 24-week treatment phase and 24-week follow-up period.

While conducting two Phase 3 clinical trials in HIV and hepatitis C infected patients respectively, the Company found that many patients are co-infected with both HIV and hepatitis C viruses. According to Dr. Andrew Talal of The Aaron Diamond AIDS Research Center in New York, one of the centers participating in this trial, ``It is estimated that approximately 10% of the HIV-infected population are co-infected with hepatitis C virus.'' This new trial will study the potential use of a single drug, ALFERON N Injection, to treat both the HIV and hepatitis C viruses simultaneously.

Two different groups of patients with chronic hepatitis C will be studied. One group will have significant HIV viral levels and the second will have low or undetectable levels of HIV. These two groups will be treated with ALFERON N Injection for 24 weeks. The patient's HCV and HIV viral levels will be evaluated throughout the treatment in order to measure the inhibitory effect of ALFERON N Injection on the replication of each virus. The patients will also be followed for an additional 24 weeks after treatment in order to evaluate the durability of any therapeutic benefit observed.

Interferon Sciences, Inc. is a biopharmaceutical company engaged in the manufacture and sale of pharmaceutical products based on its highly purified, natural-source, multispecies alpha interferon. The Company's ALFERON N Injection (Interferon Alfa-n3) product has been approved by the United States Food and Drug Administration for the treatment of certain types of genital warts, and is being studied for potential use in other indications. The Company also has other natural-source alpha interferon formulations in various stages of development for the potential treatment of viral and immune system diseases.

Interferon Sciences' press releases are posted on the Company's website located at http://www.interferonsciences.com. They are also available by facsimile 24 hours per day at no charge by calling PR Newswire's Company News On-Call at 800-758-5804, ext. 445138.

The forward-looking statements contained herein reflect ISI management's current views with respect to future events and financial performance. These forward-looking statements are subject to certain risks and uncertainties that could cause actual results to differ materially from those in the forward- looking statements, all of which are difficult to predict and many of which are beyond the control of ISI, including, but not limited to, those risks and uncertainties detailed in ISI's periodic reports and registration statements filed with the Securities and Exchange Commission.

SOURCE: Interferon Sciences, Inc.

Copyright (c) 1997/PR NewsWire. Reproduced with permission. Reproduction of this article (other than one copy for personal reference) must be cleared through the Permissions Desk, PR Newswire, 810 Seventh Avenue, New York, NY 10019.
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