Howard Hughes Medical Institute - November 13, 2008
Xiaowei Zhuang, Ph.D., HHMI Investigator
Call it the bullet train of enzymes. Howard Hughes Medical Institute (HHMI) researchers have found that HIV reverse transcriptase exhibits a stunning display of enzymatic dynamics as it zooms back and forth on the very DNA it is building. Each of the DNA s two strands serves as a rail, with reverse transcriptase - an e
Robert F. Siliciano, M.D., Ph.D., HHMI Investigator
For patients who have access to the latest retroviral therapies, HIV is no longer the sure killer it once was. The development of drug cocktails--three-drug combinations known as highly active antiretroviral therapies (HAART)--has made it possible to keep the virus at bay. But while dozens of drugs target specific stag
Howard Hughes Medical Institute - January 10, 2008
Stephen J. Elledge, Ph.D., HHMI Investigator
Like all viruses, the human immunodeficiency virus (HIV) depends on its host cell to do much of its molecular dirty work as it promotes infection. Now, in a paper published online January 10, 2008, in Science Express, a team of researchers from the Howard Hughes Medical Institute (HHMI) has provided a detailed picture
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