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Updated Pediatric Treatment Guidelines available

Food and Drug Administration - February 29, 2008
Richard Klein & Kimberly Struble

The Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection have been revised. The new version includes updated information on:

When to initiate therapy, including

• Change in treatment recommendations for when to initiate therapy in HIV-infected children <12 months of age

• Reduction from 4 to 3 age bands for recommendations on when to initiate therapy (<12 months, 1 to <5 years, and 5 years and older)

• Changes in immunologic thresholds for when to start in children 1 year or older

• Timing of diagnostic testing in HIV-exposed infants

• The pediatric drug appendix and hyperlink on drug preparations, new dosage formulations, and pediatric studies

• Recently approved antiretrovirals: maraviroc (including a new coreceptor tropism assay section), raltegravir, and etravirine

• Revised antiretroviral toxicity hyperlink with new tables detailing toxicity management

Changes are highlighted in yellow throughout the text and tables.

The updated guidelines are available for download from the Pediatric Guidelines section of the AIDSinfo Web site. You can also request to receive them by mail or email from the AIDSinfo Order Publications section.

Richard Klein
Office of Special Health Issues
Food and Drug Administration

Kimberly Struble
Division of Antiviral Drug Products
Food and Drug Administration


080229
FD080205

SOURCE: Food and Drug Administration (FDA).

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Always watch for outdated information. This article first appeared in 2008. This material is designed to support, not replace, the relationship that exists between you and your doctor.

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