AEGiS-FDA: FDA/Bristol Myers Squibb issues caution for HIV combination therapy with Zerit and Videx in pregnant women Food and Drug AdministrationImportant note: Information in this article was accurate in 2001. The state of the art may have changed since the publication date.
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FDA/Bristol Myers Squibb issues caution for HIV combination therapy with Zerit and Videx in pregnant women

Food and Drug Administration - January 5, 2001

FDA and Bristol Myers Squibb are warning health care professionals that pregnant women may be at increased risk of fatal lactic acidosis when prescribed the combination of the HIV drugs stavudine (Zerit) and didanosine (Videx or Videx EC) with other antiretroviral agents.

Lactic acidosis occurs when cells of the body are unable to convert food into usable energy. As a result, excess acid accumulates in the body and vital organs such as the liver or pancreas may be damaged. Severe lactic acidosis is an infrequent, but well-described complication of the class of HIV drugs known as nucleoside analogues. Pancreatitis is also a well-described complication of Videx and Zerit.
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SOURCE: Food and Drug Administration (FDA).

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