AEGiS-AP: AIDS Drug Cuts HIV Levels in Tests Associated PressImportant note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.
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AIDS Drug Cuts HIV Levels in Tests

Associated Press - Monday, November 02, 1998


NEW YORK (AP) -- An experimental AIDS drug cut HIV levels in patients' blood by as much as about 99 percent in two weeks, a preliminary study found.

That's as potent as currently approved drugs, which can drive the AIDS virus down to undetectable levels when taken longer. The experimental drug showed the 99-percent reductions in the four patients who took the highest dose.

The drug, called T-20, sabotages HIV's machinery for penetrating into the body's cells, a different strategy from that used in approved HIV medications.

Unlike the standard medications, T-20 wouldn't work as a pill. So it was given by injection to the 16 patients in the two-week study. Results are reported in the November issue of the journal Nature Medicine by scientists at the University of Alabama at Birmingham, the drug company Trimeris, Inc., of Durham, N.C., and elsewhere. Trimeris is developing T-20.

In an accompanying editorial, Dr. Douglas Richman of the University of California, San Diego, cautioned that much more study will be needed to assess how useful T-20 might be.

Scientists will have to investigate side effects when T-20 is taken long-term, as well as the possibility that HIV will become resistant with chronic therapy, he wrote.
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