
New York Times (10.10.06) - Tuesday, October 10, 2006
Lawrence K. Altman
"It's the first formal way to track HIV/AIDS treatments and outcomes on a broad, comprehensive scale and in real time," said Dr. Michael Saag, leader of the University of Alabama- Birmingham (UAB)-based project.
Typical clinical AIDS drug trials restrict participants who have other illnesses and are often short-term evaluations lasting weeks or months. To refine and improve patients' treatment options, researchers need more data that accurately reflect the patient population. "Just when we think we know that what we are doing is right, we get surprised" by unintended treatment complications, said Saag.
Treatment complications can include lipodystrophy, high blood pressure, diabetes, and heart disease. Treatment complications and treatment-complicating ailments will be researchable by an expanded treatment outcomes database.
Safeguards will ensure patients' identities remain confidential. Besides therapy, the databases will include information about patient symptoms, body image, adherence, and lab tests. The data could be used in basic analyses of disease progression, difficult-to-Detect illnesses including mental health problems, and to extrapolate the best treatment options for a patient.
Chosen for their existing, accurate treatment databases, participating centers are UAB, Case Western Reserve University in Cleveland; Harvard University in Boston; Johns Hopkins University in Baltimore; the Universities of California in San Diego and San Francisco; and the University of Washington- Seattle. The grant can accommodate up to five additional centers.
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