Important note: Information in this article was accurate in 2003. The state of the art may have changed since the publication date.
Hepatitis Weekly (09.08.03) - Thursday, October 09, 2003
"In 1997, a 27-year-old homosexual man contracted acute hepatitis B that developed into chronic hepatitis," R. Joh and colleagues at Tokyo Women's Medical University, Institute of Gastroenterology, wrote. "Because of repeated flares, administration of lamivudine was started in March 2002. Hepatitis B virus (HBV) DNA immediately decreased, but the serum level of alanine aminotransferase gradually increased."
The scientists excluded the possibility of drug-induced hepatitis from lamivudine, and suspected that the progression of liver damage was caused by HDV, "because the patient was positive for both anti-HDV antibody and HDV RNA," the investigators found. Their study, "Chronic Hepatitis B with Flare Due to Co-Infection of Hepatitis Delta Virus during Lamivudine Therapy" appeared in Internal Medicine (2003;42(7):581-586).
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