Risk Factors for the Rising Rates of Primary Liver Cancer in the United States

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date.

Risk Factors for the Rising Rates of Primary Liver Cancer in the United States

Archives of Internal Medicine Online (archinte.ama-assn.org) (11/27/00) Vol. 160, No. 21,
El-Serag, Hashem B.; Mason, Andrew C.

Researchers investigated the risk factors behind the United States' growing rate of primary liver cancer associated with hepatitis B virus (HBV), hepatitis C (HCV), and alcoholic cirrhosis. Between 1993 and 1998, more than 1,600 patients in the Department of Veterans Affairs Medical Center's Patient Treatment File were diagnosed with primary liver cancer. The researchers note that the age-adjusted proportional hospitalization rate for primary liver cancer rose from 36.4 per 100,000 between 1993 and 1995 to 47.5 per 100,000 between 1996 and 1998. During these periods, there was also a significant increase in the age-adjusted rates for primary liver cancer associated with HCV. The age-adjusted rates for HCV-associated primary liver cancer also shifted toward younger patients during this time. Meanwhile, the age- adjusted rates of primary liver cancer associated with HBV or alcoholic cirrhosis remained stable during the study period, as did the rates of primary liver cancer without risk factors.
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