U.S. Bioscience Suspends Test of AIDS Drug Lodenosine

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

U.S. Bioscience Suspends Test of AIDS Drug Lodenosine

Wall Street Journal (10/15/99) P. B2
Winslow, Ron

Just three weeks after agreeing to be acquired by MedImmune, U.S. Bioscience Thursday said it halted clinical trials of its AIDS drug lodenosine because one patient died and others exhibited signs of potential liver or kidney damage. Company officials noted that all patients in the trial have stopped using lodenosine and were still taking other drugs used in the trial, including Merck's Crixivan and Bristol-Myers Squibb's Zerit. The company indicated that the problems were discovered after positive preliminary results were reported at a meeting in San Francisco last month. U.S. Bioscience plans to review the data and work with the Food and Drug Administration to decide on a future course of action, which could include indefinitely suspending the testing.

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