Low-Dose Ritonavir Extends Half-Life of Indinavir

Important note: Information in this article was accurate in 1999. The state of the art may have changed since the publication date.

Low-Dose Ritonavir Extends Half-Life of Indinavir

Reuters Health Information Services (10/08/99)

A new study in the journal AIDS indicates that adding ritonavir to indinavir in a twice-daily dosing regimen increases the pharmacokinetic profile of indinavir. Scientists from the Netherlands evaluated three cocktail variations in 12 patients infected with HIV. The investigators found that the peak concentration of indinavir was higher and trough levels lower when patients were given 1200 mg two times a day, when compared to results from patients given 800 mg indinavir plus 100 mg ritonavir; the addition of the ritonavir dosage raised the chance of toxicity, and patients on that combination suffered more side effects. In comparison, adding the same dose of ritonavir to 800 mg indinavir twice daily improved the pharmacokinetic profile.

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