Peripheral Neuropathy/Myopathy Common Side Effects of HIV Antiretrovirals

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Peripheral Neuropathy/Myopathy Common Side Effects of HIV Antiretrovirals

Reuters Health Information Services (12/30/98)

Members of the AIDS Clinical Trials Group 175/801 report that therapy with currently recommended antiretroviral drugs for HIV infection could produce symmetrical neuropathy and myopathy. Of nearly 2,500 patients studied, 222 site diagnoses of neuropathy were made, about half of which were cases of distal symmetrical neuropathy. Patients receiving zidovudine and zalcitabine had the highest rates of distal symmetrical neuropathy. The researchers, who reported their findings in the Dec. 24 issue of AIDS, said that because neuromuscular complications are common antiretroviral therapy- related effects, dose modifications may be required.

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