Triple-Drug Therapy Does Not Restore Most Immune Markers in Pediatric AIDS

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Triple-Drug Therapy Does Not Restore Most Immune Markers in Pediatric AIDS

Reuters Health Information Services (12/29/98)

New research from the National Cancer Institute indicates that triple-drug therapy with a protease inhibitor does not restore most cellular immune markers in pediatric AIDS patients after six months. The study, published in the Dec. 24 issue of AIDS, investigated the immunological status of 89 HIV-infected children who were given protease inhibitor monotherapy for three to four months and then triple-drug therapy for another three months. While viral loads decline and CD4 T-lymphocyte counts increased significantly, the researchers note that there was no difference in immune parameters among children treated with mono- or triple-drug therapy.

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