Differences in Contributing Factors to Tuberculosis Incidence in U.S.-Born and Foreign-Born Persons

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Differences in Contributing Factors to Tuberculosis Incidence in U.S.-Born and Foreign-Born Persons

American Journal of Respiratory and Critical Care Medicine Online (12/98) Vol. 158, No. 6, P. 1797
Chin, Daniel P.; Deriemer, Kathryn; Small, Peter M.; et al.

Researchers in San Francisco analyzed tuberculosis incidence among 367 patients with strains of Mycobacterium tuberculosis recently introduced into the city to determine the factors contributing to disease incidence in U.S.-born and foreign- born populations. Using restriction length polymorphism fragment analysis, the scientist clustered the patients according to strain similarity. They then reviewed patient medical records and interviewed the patients to determine the likelihood of transmission between clusters. They found that none of the 252 foreign-born patients became infected in San Francisco within the past two years. Seventeen percent of 115 U.S.-born patients were infected in the city within two years, with only two contracting the disease from a foreign-born patient. The authors note that recent infection in the city was associated with HIV infection, homelessness, or drug abuse.

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