Early Treatment of HIV-1 Infection

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date.

Early Treatment of HIV-1 Infection

Lancet (12/12/98) Vol. 352, No. 9144, P. 1935
Fauci, Anthony; Bartlett, John G.; Goosby, Eric; et al.

In a letter to the Lancet, Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, and others comment on a recent Lancet viewpoint by Jay Levy, of the University of California at San Francisco. Fauci et al. state that Levy's call for caution in the early treatment of HIV-1 infection is valid; however, they note that Department of Health and Human Services' guidelines of HIV treatment are meant to be flexible. The guidelines say that "the strength of this recommendation [for treatment] is dependent on patient acceptance, probability of adherence, and prognosis as indicated by the CD4 cell count and the viral burden." In response, Levy points out that the late treatment of HIV-1 infection can result in positive immune responses.

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